康静波 聂青 张丽萍 李启亮  李建国齐文杰           海军总医院 放疗科 北京  100037

摘要  目的：分析伽玛刀配合放射增敏剂和介入化疗栓塞治疗原发性肝癌的临床效果。方法：自2005年3月至2007年3月，收治81例原发性肝癌病人。46例给与体部伽玛刀配合放射增敏剂治疗， 35例给与伽玛刀配合放射增敏剂及介入化疗栓塞治疗。结果：治疗后3个月总的有效率为85.2%(69/81) 。伽玛刀配合放射增敏剂组的１年、2年局部控制率分别为63.0%(29/46)、34.8%(16/46),1年、2年生存率分别为65.2％、37.0％。伽玛刀配合放射增敏剂及介入化疗栓塞组的1年、2年局部控制率分别为68.6%(24/35)、37.1%(13/35)，1年、2年生存率分别为71.4％、42.9％。随访期内未见严重放射性并发症。结论：对原发性肝癌采用伽玛刀配合放射增敏剂和介入化疗栓塞进行治疗是较有效的局部治疗方式。

关键词：原发性肝癌，伽玛刀，放射增敏剂，介入化疗栓塞治疗

The Clinical Study of  γ-knife  combined with radiosensitizer and chemoembolization（TACE） For Primary Hepatocellular Carcinoma.

              Kang Jingbo， Nie Qing ,Zhang liping ,et al.

　　　　　　   Navy General  Hospital ( Beijing  100037 )

 Abstract:   The purpose:   To investigate the clinical  effect  of  γ-knife Combining  with radiosensitizer and chemoembolization（TACE） for  primary  hepatocellular carcinoma.Methods:eighty-one patients with primary  hepatocellular carcinoma were treated from  March 2005 to March 2007  .Among which ,46 patients were treated by whole Body γ-knife  combined with radiosensitizer,35 patients were treated by whole Body γ-knife  combined with radiosensitizer and chemoembolization.Results : Three months  after treatment, the over response rate was   85.2%(69/81).  The local control rate at  1、2 years  was 63.0%(29/46)、34.8%(16/46)，the survival rate at 1、2 years was ６5.2％、37.0％, respectively in γ-knife combined with radiosensitizer group．The local control rate at  1、2 years  was 68.6%(24/35)、37.1%(13/35),the survival rate at 1、2 years was 71.4％、42.9％,respectively inγ-knife combined with radiosensitizer and chemoembolization.．No serious complications were found in the  follow up period.Conclusion: γ-knife combining  with radiosensitizer and chemoembolization.  is  an  effective  treatment for the primary  hepatocellular carcinoma.